GRUDIZ 2.5MG TAB 10s
How it works
Letrozole is a nonsteroidal competitive inhibitor of the aromatase enzyme system; it inhibits the conversion of androgens to estrogens. In adult nontumor- and tumor-bearing female animals, letrozole is as effective as ovariectomy in reducing uterine weight, elevating serum LH, and causing the regression of estrogen-dependent tumors. In contrast to ovariectomy, treatment with letrozole does not lead to an increase in serum FSH. Letrozole selectively inhibits gonadal steroidogenesis but has no significant effect on adrenal mineralocorticoid or glucocorticoid synthesis.
Grudiz Tablets Usage And Safety
Dosage
Letrozole
Side Effects
Common or very common: Abdominal pain ,alopecia, anorexia, appetite increase, arthralgia, bone fracture, Constipation, depression, diarrhea, dizziness, dry skin, dyspepsia, fatigue, headache, hot flushes, hyper cholesterolaemia, hypertension, increased sweating, musculoskeletal pain, nausea, osteoporosis, peripheral oedema, rash, vaginal bleeding, vomiting, weight changes. Uncommon: Anxiety, arthritis, blurred vision, breast pain, cardiac events, cataract, cerebrovascular events, cough, Dysaesthesia, dyspnea, eye irritation, general oedema, insomnia, leucopenia, memory impairment, mucosal Dryness, palpitation, pruritus, pyrexia, stomatitis, tachycardia, taste disturbance, thrombophlebitis, tumour pain, urinary frequency, urinary-tract infection, urticaria. vaginal discharge. Rare: Arterial thrombosis . pulmonary embolism. Frequency not known: Hepatitis ,toxic epidermal necrolysis.