NEXUM IV 40MG INJECTION

Product Overview

NEXUM IV Injection contains 40 mg of esomeprazole sodium, a potent proton pump inhibitor (PPI) designed for intravenous administration. It’s ideal when oral intake is not possible or rapid acid suppression is required. 

🩺 Indications

• Erosive esophagitis and Gastroesophageal Reflux Disease (GERD)

• Gastric and duodenal ulcers, including those associated with NSAID therapy

• Zollinger‑Ellison syndrome and other hyperacidity conditions

• Prevention of ulcer re-bleeding after endoscopic procedures with high-risk ulcers 

⚙️ How It Works

Esomeprazole irreversibly inhibits the gastric parietal cell proton pump (H⁺/K⁺‑ATPase), decreasing stomach acid secretion and significantly increasing gastric pH. 

💡 Dosage & Administration

• Adults: 20–40 mg via IV injection over at least 3 minutes or infusion over 10–30 minutes once daily; in acute ulcers, an 80 mg infusion over 30 minutes followed by continuous infusion of 8 mg/hr over 72 hours may be used before switching to oral therapy 

• Pediatric use (1–18 years): 10–40 mg once daily, dosage based on age and clinical indication 

✅ Key Benefits

• Rapid relief of acute acid-related conditions

• Suitable when oral medication is not feasible (e.g., pre/post-surgery, ICU settings)

• Professional-grade delivery for controlled plasma concentration and consistent efficacy

⚠️ Side Effects

Common (≥1/100):

• Headache, nausea, abdominal discomfort, diarrhea, flatulence, skin reactions, dry mouth 

Uncommon (≥1/1,000, <1/100):

• Blood count anomalies (e.g. leukopenia, thrombocytopenia), hyponatremia, neuropsychiatric effects like agitation or confusion, taste changes, bronchospasm, oral inflammation, fungal gut infections, liver dysfunction (jaundice), alopecia, rash from sun exposure, arthralgia/myalgia, general malaise and fatigue 

Rare (<1/10,000):

• Agranulocytosis, hallucinations, severe skin reactions (e.g. Stevens-Johnson syndrome), kidney failure, gynecomastia in men, severe liver toxicity, muscle weakness 

Other effects:

• Long-term PPI use risks include hypomagnesemia, vitamin B₁₂ deficiency, and increased risk of bone fractures (hip, wrist, spine) especially in elderly or long-duration users