REZNA 80MG TAB 14s

Resmetirom is a partial agonist of the thyroid hormone receptor-beta (THR-ß). Resmetirom produced 83.8% of the maximum response compared to triiodothyronine (T3), with an EC50 of 0.21 µM in an in vitro functional assay for THR-ß activation. The same functional assay for thyroid hormone receptor-alpha (THR-a) agonism showed 48.6% efficacy for Resmetirom relative to T3, with an EC50 of 3.74 µM. THR-ß is the major form of THR in the liver, and stimulation of THR-ß in the liver reduces intrahepatic triglycerides, whereas actions of thyroid hormone outside the liver, including in heart and bone, are largely mediated through THR-a.