RONIM INJ 500MG

Doripenem belongs to the carbapenem class of antimicrobials. Doripenem exerts its bactericidal activity by inhibiting bacterial cell wall biosynthesis. Doripenem inactivates multiple essential penicillin-binding proteins (PBPs) resulting in inhibition of cell wall synthesis with subsequent cell death. In E. coli and P. aeruginosa, doripenem binds to PBP 2, which is involved in the maintenance of cell shape, as well as to PBPs 3 and 4.

Dosage

Doripenem

Side Effects

Gastrointestinal disorders : Diarrhea , Nausea , Vomiting ; Investigations : Hepatic enzyme increased , Gamma-glutamyltransferase increased ; Nervous system disorders : Headache , Vascular disorders , Phlebitis ; Skin and subcutaneous tissue disorders : Rash